Enteroviruses represent a major medical threat, but unfortunately, there are no approved antivirals.
Vaccines are only available against Polio Virus, and developing vaccines against all strains, is not feasible due to the sheer quantity of serotypes.
Rhinoviruses alone number more than 150 serotypes, and there are 28 coxsackie A viruses, 6 coxsackie B viruses, 28 echoviruses, 3 polioviruses, and 38 numbered enteroviruses.
EV Replication Cycle
The replication cycle of Enteroviruses involves a number of critical steps, all of which could be promising targets for drug discovery. Certain drugs are more effective early in the replication cycle, while other drugs, exert their activity later in the replication cycle.
Combining antivirals that inhibit EV replication at different stages of the EV life cycle, could be an ideal treatment regimen for patients chronically infected with Enteroviruses.
Viral RNA replication
Potential antivirals could be targeted towards the viral capsid or the viral protease, which is critical early in the replication cycle of the virus.
A small molecule inhibitor, or a protease inhibitor could also be used to inhibit EV replication. They both exert their antiviral activity at a later stage in the replication cycle.
The screening of compounds led to the discovery that Itraconazole, an antifungal, had activity against Enteroviruses, and that Prozac, a selective serotonin re-uptake inhibitor, also had antiviral activity against EV.
Since there are no approved antiviral drugs to treat enterovirus infections, treatment is limited to supportive and symptomatic care.
The following are commonly prescribed medications to treat symptoms:
High dose Vitamins and herbs
In addition to suppressing viral replication, there are also medications that can stimulate the immune system, or help regulate its response.
Equilibrant is composed of a proprietary blend of vitamins, minerals and herbs that have been selected specifically for their individual immune system supporting properties. When used in the proper combination, these ingredients provide enhanced support for immune system balance, which promotes health and well-being.
Most patients start with 1 tablet per day, increasing after two weeks to 2 tablets per day.
Anatabloc battles chronic inflammation. It leverages the body’s natural process for regulating its own inflammation by using anatabine, a natural alkaloid found in Solanaceous plants (tomato, peppers, tobacco).
Pre-clinical studies have shown that Anatabloc inhibits pro-inflammatory pathways, thereby helping maintain lower levels of inflammation.
Anatabine has been shown to have significant anti-inflammatory effects in-vitro, in animal studies, and in human epidemiological studies of tobacco alkaloid exposures.
Clinical trials are underway for Crohn's, IBS, and other disorders.
Immune Strengthening Diet
Eating a well balanced diet, with lots of fruits and vegetables strengthens the immune system.
Probotics or live cultures (found in yogurt) can also strengthen the GI tract. EV thrives in an acidic environment, so foods high in acid such as tomatoes may irritate the stomach.
Acid blockers may help reduce the production of acid in the stomach, as well as symptoms of indigestion.
Food allergies are common among patients with chronic EV infections, so consult an allergist to determine what foods and spices can be irritating.
It's possible to have the onset of celiac sprue (sensitivity to gluten) after an EV infection.
The Body Ecology system of health and healing comprise three simple dietary transitions that can have a profound impact on how you feel:
The addition of cultured foods to your diet
Changing the quality of fats and oils you consume
Drastically reducing your intake of carbohydrates and sugars
Adequate rest is extremely important.
If insomnia occurs, please consult with your doctor about possible sleep aids.
Biofeedback and cognitive conditioning may be helpful. Physical therapy may help intensify muscle pain and debility.
Graded exercise can be tried, as tolerated, but the results are not as promising as reported by the British investigators.